There is a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to lower afferent ache transmission and produce analgesia. For that reason, medicines like clonidine that target alpha-2 receptors can affect the transmission of pain. : linked to, served by, https://www.proleviate.com/post/the-new-pain-killer-conolidine