You will find a launch of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to decrease afferent suffering transmission and make analgesia. Therefore, medicine like clonidine that target alpha-2 receptors can influence the transmission of suffering. Clonidine is distributed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine